Gabatarwar NAD Pre-Cursor

NAD + wani muhimmin coenzyme ne, wanda cikakken sunansa shine nicotinamide adenine dinucleotide. Ya wanzu sosai a cikin sel kuma yana shiga cikin mahimman halayen ƙwayoyin halitta masu yawa. NAD + tana taka muhimmiyar rawa a yawancin hanyoyin rayuwa, gami da makamashin kuzari, numfashi ta salula, gyaran DNA, kwafin kwayoyin halitta, da tsufa. Yana iya samun ko saki electrons daga gare ta ta hanyar halayen biocatalytic iri-iri. A cikin wannan tsari, halayen da NAD + na iya haɓakawa sun haɗa da redox, rage carbonyl, canja wurin acyl, da dai sauransu. A matsayin coenzyme, NAD + babban aikin shine don canja wurin electrons da hydrogen ions a cikin halayen enzyme-catalyzed. A lokacin wannan tsari, NAD + yana raguwa zuwa NADH, ta haka yana samar da electrons da hydrogen ions don sauran halayen enzyme da ake bukata. NAD+ ya kuma ja hankalin kimiyya sosai a cikin 'yan shekarun nan saboda ana tunanin yana da hannu a tsarin tsufa. Nazarin ya gano cewa yayin aiwatar da tsufa, matakin NAD + a cikin sel yana raguwa, kuma ƙarin NAD + na iya haɓaka metabolism na makamashin salula, gyaran DNA da jinkirta tsufa. Bugu da ƙari, an kuma gano NAD + don taka muhimmiyar rawa wajen gyara lalacewar DNA, apoptosis, kunna enzymes da daidaita maganganun kwayoyin halitta. A halin yanzu, mutane suna gudanar da bincike mai zurfi akan NAD + da rawar da yake takawa a cikin ilimin halittar jiki da ilimin halittu, don samun ƙarin bayani game da ayyuka da aikace-aikacen NAD +.