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NMNH, labari kuma mai ƙarfi NAD precursor
2024-08-27 10:00:38
Nicotinamide adenine dinucleotide (NAD) homeostasis yana ci gaba da lalacewa saboda lalacewa ta hanyar enzymes masu dogaro da NAD. Haɓaka NAD tare da abubuwan NAD nicotinamide mononucleotide (NMN) da nicotinamide riboside (NR) na iya rage wannan rashin daidaituwa. Wasu masu bincike sun ba da rahoton hanyar haɗin kai na rage nau'in NMN,NMNH, kuma sun gano wannan kwayar halitta a matsayin sabon ma'auni na NAD a karon farko, kuma ya tabbatar da cewa NMNH ya fi NMN da NR inganci wajen haɓaka matakan NAD kuma yana iya rage girman tubule na renal. Kwayoyin Epithelial sun lalace kuma ana hanzarta gyara su. An buga sakamakon a cikin "Jarida ta FASEB".
Enzymatic kira na NMNH: Babban aiki na NAD pyrophosphatase daga Escherichia coli (EcNADD) ana amfani dashi don raba NADH cikin NMNH da AMP.
NMNHyana haɓaka abun ciki na NAD yadda ya kamata:
Don tabbatar da ko NMNH na iya haɓaka abun ciki na NAD yadda ya kamata, an yi allurai daban-daban na NMN da NMNH cikin ƙwayoyin hanta na mice AML12. Sakamakon ya nuna cewa a kowane maida hankali, NMNH ya karu matakin NAD sama da NMN. A lokaci guda, matakan NAD sun karu sosai a cikin mintuna 15 ta amfani da NMNH a matsayin maƙasudi, yana tabbatar da cewa NMNH shine mafi sauri fiye da NMN; kuma idan aka kwatanta da NMN, NMNH ya haɓaka matakan NAD da sau 1.3-2.4. Samun damar haɓaka matakan NAD daga sau 5.2 zuwa sau 37 yana tabbatar da cewa NMNH babban mafari ne mai inganci don haɗin NAD.
Don kwatanta sakamakon NMNH da NMN, masu bincike sun yi allurar PBS da 250 mg / kg na NMN daNMNHzuwa cikin berayen C57BL/6N, bi da bi, sannan kuma an gudanar da gwajin jini na jeri. Sakamakon ya nuna cewa NMNH yana haɓaka matakan NAD a cikin jini sosai, zuwa mafi girma fiye da NMN. An auna NAD akan kyallen da aka tattara ta hanyar tsarin zagayowar enzyme. Sakamakon ya nuna cewa NMNH ya karu da matakan NAD a cikin kyallen takarda daban-daban, kuma tasirin ya fi na NMN. Yana da tasirin gaske akan hanta da koda, tare da hanta yana ƙaruwa da fiye da sau 5 kuma koda yana ƙaruwa da fiye da sau 5. sau 2.
NMNHYana kare sel tubular epithelial na koda daga lalacewa:
A cikin koda, ƙwayoyin epithelial na kusa da tubular sun fi dacewa da raunin ischemic saboda kai tsaye yana rinjayar metabolism na makamashi kuma yana sanya damuwa mai mahimmanci akan metabolism na NAD a cikin epithelium. Rashin daidaituwa a cikin hanyoyin rayuwa da kuma rage ikon gyara lalacewar tsarin epithelial yana haifar da cutar koda. Shin za a iya haɓaka matakan NAD ta hanyar allurar NMNH na waje da kyau yadda ya kamata ya dawo da ƙwayoyin epithelial da suka lalace yadda ya kamata? Gudanar da NMNH a ƙarƙashin yanayin al'ada ya karu da abun ciki na NAD 5-ninka, yayin da a daidai wannan taro, tasirin NMN ya kasance ƙasa da na NMNH. Duk abubuwan da suka gabata na NAD sun ƙara haɓaka abun ciki na NAD a cikin sel tubular epithelial na koda a ƙarƙashin yanayin hypoxic, har ma sama da yanayin al'ada. An ga irin wannan yanayin a cikin al'adar hepatocytes, inda gudanar da NMNH kuma ya haifar da karuwa a cikin abubuwan da ke da alaka da NAD zuwa mafi girma fiye da NMN.
An ƙara NMNH a lokacin lokacin reoxygenation, kuma an gano alamar alamar rauni tubular renal KIM-1. Reoxygenation a cikin TEC ya haifar da karuwa mai girma a cikin KIM-1 magana, wanda ya ragu sosai bayan jiyya na NMNH, yana nuna cewa gudanarwa naNMNHzai iya da kyau da mahimmanci rage lalacewa ga sel tubular epithelial na koda yayin hypoxia da reoxygenation.
Hanyar LafiyaNMNHharbi na gaske
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Irene@xahealthway.com
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Wayar Hannu: 86 18691558819
Irene@xahealthway.com
www.xahealthway.com
Shafin: 18691558819
WhatsApp: 86 18691558819
