Tsufa ɗan adam doka ce ta duniya. "Biochemistry da Cell Biology of Aging" ya taƙaita shekarun da suka gabata na bincike na tsufa da kuma halayen tsufa zuwa lalacewar oxidative da raguwa a cikin matakan NAD +.
Ana iya ganin cewa NAD + tana taka muhimmiyar rawa a cikin kwayoyin halitta, kuma tana da alaƙa ta kut da kut da cututtuka da cututtuka.
Ana kiran NAD + nicotinamide adenine dinucleotide, ko coenzyme I a takaice. Yana da hannu sosai a cikin nau'o'in ayyukan ilimin lissafi na asali a cikin kwayoyin halitta, ta haka yana rinjayar farfadowa na makamashi, juriya ga lalacewar oxidative, gyaran DNA, tsara kwayoyin halitta da kwayoyin halitta waɗanda ke sarrafa tsufa a cikin sel, raunana ko ma rufe wasu kwayoyin tsufa, ta yadda ya kamata jinkirta jinkiri. ci gaban jerin gwano. A ƙasa, bari mu kalli cikakken bayani:
1.Muhimmancin NAD+
A matsayin daya daga cikin mafi mahimmancin metabolites a cikin jikin mutum, NAD + ya kasance cikin kwanciyar hankali wanda ya kunshi samar da kwayoyin halitta, cinyewa, wurare dabam dabam da lalata na dogon lokaci.
Tun daga shekarun 30s, matakin NAD + a cikin jikin mutum zai nuna yanayin ƙasa yayin da mutane suka tsufa. Ragewar NAD + a cikin sel zai haifar da raguwar ikon gyara DNA, haɓaka tarin lalacewar DNA, sannan kuma ya haifar da lalata NAD + Abubuwan da ke cikin ƙara raguwa, suna haifar da mugun yanayi na saurin tsufa da sauri.
Mun ce NAD + tana da hannu wajen gyaran DNA musamman saboda yanki ne na dangin PARP. Tare da NAD+, PARP na iya taka rawar da ta dace. A gefe guda, PARP kuma ɗaya ne daga cikin manyan "masu amfani da" NAD + a cikin sel. NAD+ da PARP ke amfani da shi ya juya ya zama nicotinamide NAM, sannan ya kwarara zuwa hanyar ceto, kuma NAD+ ta sake haɗawa tare da taimakon NAMPT, NMNAT da sauran enzymes. Lokacin da sel ke cikin damuwa (gami da hanyoyin gyaran DNA), an haɗa yawancin NAD + ta hanyar ceto don kiyaye daidaito tsakanin wadata da buƙata.
NAD + yana shiga cikin gyaran DNA azaman siginar Sirtuins
Sirtuins iyali ne na furotin deacetylase wanda ya ƙunshi mambobi 7 (SIRT1-SIRT7). SIRT1, SIRT6, da SIRT7 sun kasance a cikin tsakiya, SIRT2 tana taka rawa a cikin cytoplasm, kuma SIRT3, SIRT4, da SIRT5 sune sunadaran mitochondrial. Wasu Sirtuins (musamman SIRT1 da SIRT6) suna taka muhimmiyar rawa wajen gyaran DNA da kuma metabolism na salula bayan lalacewar DNA.
3.NAD + metabolism da ayyukan physiological
01. Kula da redox homeostasis
Kula da ma'auni na oxidants intracellular da antioxidants shine mabuɗin don sel don kula da ayyukan ilimin lissafi na al'ada. Duk da haka, abubuwan da ba su da kyau kamar gurbatawa, canjin abinci mai gina jiki da kamuwa da cuta na iya rushe wannan ma'auni kuma ya haifar da lalacewa ga macromolecules na halitta kamar DNA da sunadarai. Haɓakawa NAD + na iya taka rawar kariya ta oxidative ta haɓaka matakan da ayyukan glutathione da jerin enzymes antioxidant.
02. Kula da kwanciyar hankali
Rashin NAD + zai haifar da cikas ga gyaran lalacewar DNA, haifar da babban adadin lalacewar DNA don tarawa, kuma ƙarawa NAD + zai iya taimakawa gyaran DNA.
03. Daidaita matakan rigakafi da kumburi
Baya ga NAD + da kanta yana iya rage matakan kumburi da yawa ta hanyar inganta aikin lysosomal, NAMPT enzyme da ake buƙata a cikin metabolism ɗin sa shima muhimmin sashi ne na daidaita rigakafi. Ƙara NAD+ yana taimakawa wajen daidaita rigakafi da kumburi.
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Lokacin aikawa: Dec-26-2023
