01
Urolithin A: Bayan sunan baƙon, babban aikin lalata ƙwayoyin cuta Urolithin A: Ƙarfafa ƙarfin hanji na halitta.
A cikin 1980, an fara gano urolithin A (UA) a hanyar ciyar da ellagic acid (EA). Tun daga wannan lokacin, an gano kasancewar UA a cikin nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan 'ya'yan itace, gami da kwari da 'ya'yan itace. Yana da tsari iri ɗaya da kaddarorin kuma an yi nazari sosai. Duk da haka, UA yana da wuya a cikin sassan numfashi. Sai kawai lokacin da kwayoyin halitta ke cinye abubuwa masu wadata a cikin polyphenol ellagitannins na halitta (ET) ko ellagic acid (EA) (kamar rumman), tare da taimakon takamaiman tasirin microbiome, UA za a haifar da shi a cikin hasashe.
Bayan shiga cikin jini, UA za a juye juzu'i zuwa conjugates (UA-formaldehyde da UA-sulfate). Gwaje-gwajen cell in vitro sun nuna cewa UA conjugates a wannan mataki sun rasa yawancin ayyukansu na halitta.
Abin takaici, cin cikakken amfani da polyphenols na halitta da canza su zuwa UA ba abu ne mai sauƙi ba. Daukar dan Adam a matsayin misali, wani bincike na asibiti na dan Adam ya nuna cewa kashi 40 cikin 100 na mutane na iya samar da UA a jiki, kuma wannan kaso na iya raguwa saboda canje-canjen da ake samu a cikin flora na kwayoyin cuta da suka lalace sakamakon tsufa. Don haka, wasu malamai sun ba da shawarar cewa ƙara UA kai tsaye zai iya guje wa wannan matsala.
Legend: Ellagitannin (ET) ko ellagic acid (EA) na iya samar da urolithin A (UA) a ƙarƙashin aikin flora na hanji.
02
Cell "power factory quality controller",Daidaita mitophagy
Don haka, shin wannan UA shine kawai batun "abubuwan da ba kasafai suke da daraja ba", ko kuma yana da tasirin rigakafin tsufa na inganta lafiyar jiki da kuma tsayayya da alamun tsufa? A cikin adawa da mitochondria, "ma'aikatar wutar lantarki" na sel, UA ta ba da nata amsar.
Haɓaka zaɓin autophagy na mitochondria da aka lalata da kuma maido da tabarbarewar mitochondrial da ke haifar da tsufa sune manyan hanyoyin ka'idoji na UA da aka samu a yawancin nau'ikan (nematodes, mice, mutane, da sauransu). Lokacin da mitochondria ya fallasa zuwa damuwa na waje kuma ya lalace, autophagy yana farawa. UA da gaske tana aiki azaman mai haifar da autophagy kuma galibi tana shiga kuma tana sarrafa tsarin mitophagy ta hanyoyi biyu:
Na 1
PINK1/Hanya mai dogaro da Parkin A cikin hanyar mitophagy da ke dogara da ubiquitin, bayan furotin na PINK1 ya gane mitochondria mai niyya, yana tattarawa da phosphorylates da furotin mai ɗaure Parkin, tare da haɓaka haɓakar sunadaran mitochondrial, haɓaka siginar autophagy, da "gudu" zuwa phagocytes. UA yana kunna maganganun kwayoyin halittar da ke da alaƙa, yana daidaita matakan PINK1 da sunadaran Parkin, kuma yana haɓaka tsarin autophagy na mitochondrial.
Na 2
Hanyar kunna mai karɓa kai tsaye
Baya ga dogaro da hanyar PINK1/Parkin, mitochondria kuma na iya “canza hanyoyi” don amfani da wasu sunadaran masu karɓa (kamar BNIP3) don kunna tsarin autophagy kai tsaye. UA "ba za ta taɓa yin watsi da aiki a tsaye ba", tana daidaita matakin maganganun sunadaran masu karɓa. yana sauƙaƙa taruwa akan saman mitochondrial.
Labari: UA na iya kunna mitophagy ta hanyar daidaita hanyoyi daban-daban.
03.
Magance matsalolin rayuwa tare,UA tsawon rayuwa ya fito
Yin niyya ka'idojin mitochondrial, kiyaye kuzarin homeostasis na jiki, da sarrafa "injin" na sel, sunan UA ba a banza ba ne. A lokaci guda, adadi mai yawa na gwaji sun tabbatar da cewa UA yana da tasiri mai mahimmanci wajen inganta kumburi na kullum, cututtuka na zuciya da jijiyoyin jini, rashin aikin tsoka, da cututtuka na neurodegenerative. UA, wacce ba ta iya daukar hankalin masana'antar ya zuwa yanzu, da gaske tana jin kamar wata boyayyiyar dutse mai daraja a cikin teku.
Baya ga abin da ya yi kama da abin banmamaki na "warkar da duk cututtuka", dangane da "tsawon rayuwa", mahimmin ƙima mai mahimmanci don rigakafin tsufa, kodayake UA tauraro ne mai tasowa, hakika yana da alƙawarin gaske. Lokacin da samfurin kwayoyin nematodes aka ciyar da UA na dogon lokaci (daga matakin kwai zuwa mutuwa), idan aka kwatanta da ƙungiyar kulawa, UA ta kunna hanyar siginar su ta AMPK kuma suna haɓaka mitophagy sosai, yana ƙara tsawon rayuwar nematodes har zuwa 45.4%!
Labari: UA mahimmanci yana ƙara tsawon rayuwar C. elegans ta hanyar dogaro da kashi
A cikin ƴan gwaje-gwajen asibiti na ɗan adam, kodayake UA ba ta riga an kimanta tsawon rayuwar ɗan adam ba, sakamakon gwajin da ake yi yana da kyau sosai. UA a zahiri tana daidaita lafiyar mitochondrial da tantanin halitta a cikin jiki. Lokacin da California strawberry foda, wanda ke da wadata a cikin precursors na UA, an ƙara shi zuwa abincin abinci, nauyin jiki da flora na hanji masu amfani da ke hade da tsawon rai sun inganta a cikin batutuwa masu lafiya. UA's anti-tsufa tafiya yana da daraja sa ido.
Wayar Hannu: 86 18691558819
Irene@xahealthway.com
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Lokacin aikawa: Dec-29-2023
