Yana da tasirin hanawa akan Escherichia coli, Escherichia coli, Diplococcus pneumoniae, Staphylococcus aureus, Streptococcus, Typhi da amoeba. A asibiti, an fi amfani dashi don lalata cututtuka da ƙwayoyin cuta. An kuma gano cewa wannan samfurin yana da tasirin anti-arrhythmic. Berberine yana da aikin anti-tumor a cikin vitro kuma yana iya haifar da ɓoyewar ƙwayoyin B16; daidai da cytarabinehydrochlorideyana da tasiri mai kyau a cikin vitro.
Manufar
Isoquinoline alkaloids. Tsarin kwayoyin halitta [C20H18NO4]+. Har ila yau, an san shi da berberine. Ya wanzu a cikin tsire-tsire da yawa a cikin jinsin 10 da iyalai 4 ciki har da Berberidaceae. Berberine na iya haifar da allura mai launin rawaya-kamar lu'ulu'u daga diethyl ether. Matsayin narkewa 145 ℃. Mai narkewa cikin ruwa, maras narkewa a cikin benzene, ether da chloroform. Berberine shine quaternary ammonium alkaloid, kuma solubility na gishiri a cikin ruwa kadan ne, misali, hydrochloride shine 1:500 kuma sulfate shine 1:30. Lu'ulu'u na berberine da aka samo daga ruwa ko tsarma ethanol sun ƙunshi kwayoyin 5.5 na ruwan crystal; idan crystallized daga chloroform, acetone ko benzene, sun kuma ƙunshi daidai crystallization sauran ƙarfi kwayoyin. Ana iya bi da Berberine da alkali daban-daban don samun nau'ikan berberine daban-daban guda uku: nau'in ammonium quaternary, nau'in aldehyde da nau'in barasa, daga cikinsu nau'in ammonium quaternary shine mafi karko. Berberine yana da tasirin kashe kwayoyin cuta akan hemolytic Streptococcus, Staphylococcus aureus, Neisseria gonorrheae, Freundii da Shigella dysenteriae, kuma yana haɓaka phagocytosis na farin jini. Berberine hydrochloride (wanda aka fi sani da berberine hydrochloride) an yi amfani da shi sosai don magance gastroenteritis, bacillary dysentery, da dai sauransu, kuma yana da wasu tasiri akan tarin fuka, zazzabi mai ja, matsananciyar tonsillitis da cututtuka na numfashi.
ilimin harhada magunguna
pharmacodynamics
Yana da bakan ƙwayoyin cuta mai faɗi kuma yana da tasirin kashe ƙwayoyin cuta akan nau'ikan ƙwayoyin cuta na Gram-positive da -mara kyau a cikin vitro, gami da hemolytic Streptococcus, Staphylococcus aureus, da Vibrio cholerae. Meningococci, Shigella dysenteriae, Typhoid bacilli, Diphtheria bacilli, da dai sauransu suna da tasirin hanawa mai ƙarfi. Su ne bacteriostatic a low yawa da kuma sterilizing a high yawa. Hakanan yana da tasirin hanawa akan ƙwayoyin cuta na mura, amoeba, leptospira, da wasu fungi na fata. Gwaje-gwajen in vitro sun tabbatar da cewa berberine na iya haɓaka ikon phagocytic na leukocytes da tsarin reticuloendothelial hanta. Shigella dysenteriae, hemolytic Streptococcus, Staphylococcus aureus, da dai sauransu suna da sauƙin jure wa wannan samfurin. Babu juriya tsakanin wannan samfurin da penicillin da streptomycin.
Pharmacokinetics
Rashin sha na baki. Bayan allura, yana shiga cikin gabobin jiki daban-daban da kyallen takarda da sauri, kuma ana kiyaye tattarawar jini na ɗan lokaci kaɗan. Matsalolin jini bayan allurar intramuscularly ya yi ƙasa da mafi ƙarancin taro mai hanawa. Ana rarraba maganin a ko'ina, galibi a cikin zuciya, kasusuwa, huhu da hanta. Lokacin riƙewa a cikin kyallen takarda ɗan gajeren lokaci ne, kuma adadin alama kawai ya rage bayan sa'o'i 24. Yawancin magungunan suna metabolized kuma an shafe su a cikin jiki, kuma ƙasa da kashi 5% na maganin da aka yi amfani da su ana fitar da su a cikin asali a cikin sa'o'i 48.
A cewar rahotanni na baya-bayan nan, an yi imanin cewa wannan samfurin zai iya rage adadin pili a saman kwayoyin cutar, yana hana kwayoyin cuta shiga jikin mutum, kuma yana da tasirin warkewa. Har ila yau, wannan samfurin yana da tasiri akan Helicobacter kuma yana iya magance gastritis, ciki da duodenal ulcers.
An kashe kuma a yi amfani da shi tare da taka tsantsan
Ko da yake ana iya amfani da shi a cikin yara, an hana shi a cikin yara masu ƙarancin glucose-6-phosphate dehydrogenase na gado saboda wannan samfurin na iya haifar da anemia na hemolytic kuma ya haifar da jaundice.
Mummunan halayen
(1) Abubuwan da ba su da kyau a baki ba su da yawa, tare da tashin hankali lokaci-lokaci, amai, kurji da zazzabin ƙwayoyi, waɗanda ke ɓacewa bayan dakatar da maganin.
(2) Yin allura ko jiko na ciki na iya haifar da halayen kamar vasodilation, zubar da jini, da damuwa na zuciya. A lokuta masu tsanani, Aspen ciwo na iya faruwa, har ma da mutuwa. Kasar Sin ta sanar da kawar da alluran alluran na berberine hydrochloride.
Wasu ƴan mutane suna da ƙaramin rashin jin daɗi na ciki ko ciki, maƙarƙashiya ko gudawa.
Wayar Hannu: 86 18691558819
Irene@xahealthway.com
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Lokacin aikawa: Afrilu-15-2024
