Sabbin bincike a Kimiyya: Ƙara spermidine zai iya haɓaka tsarin rigakafin ƙwayar cuta

 Sabbin bincike a Kimiyya: Ƙara spermidine zai iya haɓaka tsarin rigakafin ƙwayar cuta

  Tsarin garkuwar jiki yana raguwa da shekaru, kuma tsofaffi sun fi saurin kamuwa da cututtuka da ciwon daji, da kuma hana PD-1, maganin da aka saba amfani dashi, sau da yawa ba shi da tasiri a cikin tsofaffi fiye da matasa. Bincike ya nuna cewa akwai kwayar halitta polyamine spermidine a cikin jikin dan adam wanda ke raguwa da shekaru, kuma kari da spermidine zai iya inganta ko jinkirta wasu cututtuka masu alaka da shekaru, ciki har da cututtukan tsarin rigakafi. Koyaya, alaƙar da ke tsakanin ƙarancin spermidine wanda ke tare da tsufa da haɓakar ƙwayar cuta ta T cell ba ta da tabbas.

Kwanan nan, masu bincike daga Jami'ar Kyoto a Japan sun buga takarda bincike mai suna "Spermidine yana kunna furotin trifunctional mitochondrial kuma yana inganta rigakafi na antitumor a cikin mice" a Kimiyya. Wannan binciken ya bayyana cewa spermidine yana ɗaure kai tsaye kuma yana kunna sunadaran trifunctional na mitochondrial MTP, yana haifar da oxidation fatty acid, kuma a ƙarshe yana haifar da haɓaka metabolism na mitochondrial a cikin sel CD8+ T kuma yana haɓaka rigakafin ƙwayar cuta. Sakamakon ya nuna cewa haɗakar jiyya tare da spermidine da anti-PD-1 antibody sun haɓaka haɓakar haɓakawa, samar da cytokine da kuma samar da mitochondrial ATP na CD8 + T, da kuma spermidine ya inganta aikin mitochondrial da mahimmanci kuma ya kara yawan mitochondrial fatty acid oxidation metabolism a cikin 1 hour.

Don gano ko spermidine yana kunna fatty acid oxidase (FAO) kai tsaye a cikin mitochondria, ƙungiyar binciken da aka ƙaddara ta hanyar nazarin kwayoyin halitta wanda spermidine ya ɗaure ga furotin trifunctional mitochondrial (MTP), wani enzyme na tsakiya a cikin fatty acid β-oxidation. MTP ya ƙunshi α da β subunits, dukansu suna ɗaure spermidine. Gwaje-gwajen da aka yi amfani da MTPs da aka haɗa da kuma tsarkakewa daga E. coli sun nuna cewa spermidine yana ɗaure MTPs tare da ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan ƙaƙƙarfan zumunta (dissociation constant, Kd) = 0.1 μM] kuma yana haɓaka aikin su na enzymatic fatty acid oxidation. Ƙayyadaddun ƙayyadaddun ƙayyadaddun tsarin MTPa a cikin ƙwayoyin T ya shafe tasirin tasirin spermidine akan PD-1-suppressive immunotherapy, yana nuna cewa ana buƙatar MTP don kunna T cell mai dogara da spermidine.

A ƙarshe, spermidine yana haɓaka oxidation fatty acid ta hanyar ɗaure kai tsaye da kunna MTP. Ƙarawa tare da spermidine na iya haɓaka aikin oxidation fatty acid, inganta ayyukan mitochondrial da aikin cytotoxic na sel CD8+ T. Ƙungiyar binciken tana da sabon fahimtar kaddarorin spermidine, wanda zai iya taimakawa wajen samar da dabarun hanawa da inganta sakamakon cututtukan da suka shafi shekaru da kuma magance rashin amsawa ga PD-1 inhibitory far a cikin ciwon daji, ba tare da la'akari da girman shekaru ba.