Magana akanberberine , kowa na iya zama ɗan abin da ba a sani ba, amma dole ne kowa ya san wata magana da ta saba: bebe yana cin coptis - ba zai iya gane zafin ba! Haka ne, babban abin daci a cikin coptis shine berberine, wanda shine berberine hydrochloride.
Berberine (BBR) shine isoquinoline alkaloid - C20H19NO5 wanda aka fitar daga Coptis chinensis. Ya wanzu a cikin tsire-tsire na jinsin 10 da iyalai 4 ciki har da Berberidaceae. Lu'ulu'u masu launin rawaya mai launin rawaya za a iya haɗe su daga diethyl ether, tare da wurin narkewa na 145 ° C. Suna narkewa a cikin ruwa kuma ba su narkewa a cikin benzene, diethyl ether da chloroform.
Binciken ilimin harhada magunguna na zamani ya tabbatar da cewa berberine yana da gagarumin hana ciwon zuciya, anti-arrhythmia, rage cholesterol, anti-vascular smooth muscle proliferation, inganta insulin juriya, anti-platelet, anti-mai kumburi da sauran effects. Saboda haka, yana iya zama da amfani a cikin cututtuka na zuciya da jijiyoyin jini da tsarin juyayi. Faɗin fa'ida da mahimmancin buƙatun aikace-aikacen sa ya jawo hankalin ƙara hankali. A cewar sabon bincike na asibiti, berberine yana da tasiri mai kyau akan rigakafi da magance hauhawar jini, hyperlipidemia, ciwon sukari, arrhythmia, ciwace-ciwacen daji da sauran cututtuka. Berberine hydrochloride an ba da rahoton mafi yawan rage yawan lipids na jini. BBR na iya daidaita maganganun ƙarancin mai karɓar lipoprotein LDLR kuma yana haɓaka haɓakar furotin LDL ta ƙwayoyin hanta. An canza BBR zuwa dihydroberberine (dhBBR) ta hanyar nitroreductase na intestinal flora gut microbiota, yana sa hanjin cikin sauƙi ya shafe shi. Bayan sha, an oxidized zuwa BBR a cikin nama na hanji kuma ya shiga cikin jini. Cimma rage-ragewar lipid da tasirin hypoglycemic. BBR kuma na iya inganta haɓakar makamashi. Gudanar da baka na BBR yana haifar da microbiota na gut don samar da butyrate, wanda ke shiga cikin jini kuma yana aiki akan SCFAs (gajeren sarkar fatty acid), rage lipids na jini da matakan sukari na jini.
BBR na iya haɓaka haɓakar ƙwayoyin tsibiri na pancreatic kuma yana da fa'idodi fiye da sauran magungunan ciwon sukari. Gwaje-gwaje na asibiti masu dacewa sun tabbatar da cewa berberine na iya hana fibrosis na myocardial a cikin berayen masu ciwon sukari; BBR yana da tasirin anti-platelet, yana iya ƙara abun ciki na nucleotide a cikin platelets kuma yana hana haɗuwa. Berberine haɗe tare da statins yana taka muhimmiyar rawa wajen daidaita plasma trimethylamine oxidation a cikin cututtukan zuciya da kuma hana samuwar atherosclerosis.
Berberine na kasar Sin shine manufa madadin magungunan "statin". Tun da berberine sau da yawa ya fi rahusa fiye da magungunan “statins”, gano tasirin rage yawan jini-lipid na berberine yana da ƙimar da ba za a iya faɗi ba don rigakafin da jiyya na hyperlipidemia, ciwon sukari da cututtukan zuciya.
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Lokacin aikawa: Janairu-08-2024
